H.E. Kwabena Frimpong-Boateng graduated from the University of Ghana Medical School in 1975 with MB, ChB degrees. After housemanship at the Korle-Bu Teaching Hospital, he served as a medical officer at the Komfo Anokye Teaching Hospital, where he was also a demonstrator in Gross Anatomy at the School of Medical Sciences from 1977- 1978. He had his post-graduate studies at the Hannover Medical University, Germany and qualified as general surgeon as well as cardiothoracic and vascular surgeon. He subsequently worked as a consultant cardiothoracic surgeon and was one of the pioneers of the heart transplantation programme in Hannover, where he also taught both undergraduate and postgraduate Thorax, Cardio-thoracic and Vascular Surgery. H.E. Frimpong-Boateng performed the first of scores of heart transplantations in 1985. At the time he was recognized worldwide as the first black person to have performed a heart transplant.

H.E. Frimpong-Boateng returned home in 1989 to establish the National Cardiothoracic Centre and the Ghana Heart Foundation. He joined the University of Ghana Medical School in 2000 and was promoted Associate Professor of Surgery the same year and Full Professor two years later. H.E. Frimpong-Boateng is former CEO of the Korle-Bu Teaching Hospital, former president of the Ghana Red Cross Society and past Chairman of the Public Utility Regulatory Commission (PURC). He established the National Cardiothoracic Centre at the Korle Bu Teaching Hospital and was its Founding Director. Currently, he is the President of the Ghana Heart Foundation. H.E. Frimpong-Boateng has received several awards in recognition of his medical work and service to humanity, including the Millennium Excellence and the African Heroes Award. He is the author of two books titled DEEP DOWN MY HEART: A history of Cardiothoracic Surgery in Ghana and TAMING A MONSTER: Managing Korle Bu Teaching Hospital and has contributed chapters to two other books. He has several scientific publications and conference abstracts to his credit.

H.E. Frimpong-Boateng was appointed Minister for Environment, Science, Technology and Innovation by H.E. President Nana Addo Dankwa Akufo-Addo in February 2017.